RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
SIRT3
RNA ID
RNA Type
mRNA
Alteration Pattern
hyperacetylation of glycogen synthase kinase 3b (gsk3b)
Species
homo sapiens
Detection Methods
NA
Target
GSK3B
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3B
Year
2015
Function
"Ethanol caused dose and time-dependent increase in acetylation of histone h3 at lys9, but not at lys14 or lys18. Compared with hepatocytes the ac-h3-lys9 in hscs required longer ethanol exposure. Levels of me-h3-lys9 seemed to remain unaltered. Thus increase in ac-h3-lys9 represents a nuclear-chromatin modification event in hscs exposed to ethanol."